Table 1. Atomic structures of various multidrug-resistance-associated mammalian ATP-binding cassette (ABC) transporters recently resolved by cryo-electron microscopy.
| Protein | Ligand/nucleotide/antibody-FAB | Source | Resolution (Å) | PDB ID | Ref. |
|---|---|---|---|---|---|
| P-gp (ABCB1) | UIC2-Fab | Mouse/human-S559C/S1204C | 4.14 | 6FN4 | 19 |
| P-gp (ABCB1) | UIC2-Fab, Zosuquidar | Mouse/human S559C/S1204C | 3.58 | 6FN1 | 19 |
| P-gp (ABCB1) | UIC2-Fab, Taxol | Human | 3.6 | 6QEX | 20 |
| P-gp (ABCB1) | UIC2-Fab, Zosuquidar | Mouse/human-E-Q | 3.9 | 6QEE | 20 |
| P-gp (ABCB1) | ATP | Human-E556Q/E1201Q | 3.4 | 6C0V | 23 |
| MRP1 (ABCC1) | Apo | Bovine | 3.5 | 5UJ9 | 21 |
| MRP1 (ABCC1) | LTC 4 | Bovine | 3.3 | 5UJA | 21 |
| MRP1 (ABCC1) | ATP | Bovine-E1454Q | 3.1 | 6BHU | 24 |
| ABCG2 | 5D3-Fab, Cholesterol | Human | 3.8 | 5NJ3 | 14 |
| ABCG2 | 5D3-Fab, E 1S | Human-E211Q | 3.58 | 6HCO | 25 |
| ABCG2 | 5D3-Fab, MZ29 | Human | 3.1 | 6ETI | 22 |
| ABCG2 | MZ29 | Human | 3.56 | 6FFC | 22 |
| ABCG2 | ATP | Human-E211Q | 3.09 | 6HBU | 25 |
E 1S, estrone-3-sulfate; P-gp, P-glycoprotein.