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. 2020 Jan;30(1):22–34. doi: 10.1101/gr.251561.119

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© 2020 Cai et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — PRANCR regulates expression of cell cycle and MAPK cascade genes in trans. (A) RNA-seq analysis of PRANCR-depleted keratinocytes. RNA was harvested 72 h after transduction of shRNAs. Hierarchical clustering of differentially expressed genes (greater than twofold change) in PRANCR-depleted samples (shLNC; n = 4; biological replicates of two independent PRANCR-targeting shRNAs) versus control samples (SCR; n = 4; biological replicates of two independent scrambled shRNAs). (B,C) Gene Ontology (GO) terms of genes that are down-regulated (B) or up-regulated (C) upon depletion of PRANCR.