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Overexpression of CD6 and PD-1 impairs CD8+ T cell antiviral activity. Representative staining and the frequency of splenic CD6+PD-1+ and CD6−PD-1+CD8+ T-cells expressing IFN-γ (Top), granzyme B (Middle) and perforin (bottom) in vivo. Data are from 6 macaques. Data are shown as means ± SEM. For statistical analysis, Mann-Whitney tests were performed. *p < 0.05.
