Figure 1.

HOXA11-AS and TGFβR1 are up-regulated, while miR-124-3p is down-regulated in keloid tissues or fibroblasts.

(a) A total of 20 keloid tissues and 20 normal skin tissues were acquired from patients or healthy individuals. HE staining (left panels), IHC (middle panels), and IF staining of TGFβR1 (right panels) were performed. Scale bar, 300 μm. (b) and (c) In keloid tissues and matching normal skin tissues, the expression patterns of HOXA11-AS, miR-124-3p and TGFβR1 were measured by qRT-PCR and western blot analysis, respectively. (d) and (e) qRT-PCR and western blot analysis were subjected to detect the expression of HOXA11-AS, miR-124-3p and TGFβR1 in HKFs vs. HSFs. *P < 0.05, **P < 0.01, ***P < 0.001.