Figure 2.

HOXA11-AS suppresses apoptosis of fibroblasts and promotes fibroblast-mediated angiogenesis.

(a) qRT-PCR assay was performed to examine the expression of HOXA11-AS, demonstrating the efficacy of overexpressing or knocking down HOXA11-AS. (b–d) Cell apoptosis was examined using TUNEL assay (b), flow cytometry (c), and DNA fragmentation (d). (e) HUVECs were seeded onto Matrigel and co-cultured with HSFs or HKFs separated by a transwell membrane. The tube formation of HUVECs was imaged after 3, 5, and 6 h, respectively. *P < 0.05, **P < 0.01.