Figure 4.

Effects of miR-124-3p on HOXA11-AS-regulated apoptosis and fibroblast-induced angiogenesis.

HSFs were transfected with plv-ctrl, plv-HOXA11-AS+mimic NC, or plv-HOXA11-AS+miR-124-3p mimic; HKFs were transfected with shNC, shHOXA11-AS+inhibitor NC, or shHOXA11-AS+miR-124-3p inhibitor. (a) qRT-PCR assay was performed to examine the expression of miR-124-3p. (b and c) Cell apoptosis was examined by TUNEL assay (b), flow cytometry (c). (d) HUVECs were seeded onto Matrigel and co-cultured with HSFs or HKFs separated by a transwell membrane. The tube formation of HUVECs was detected. *P < 0.05, **P < 0.01.