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Deregulation of CCND1 in human cancers. (a) The frequencies of mutation, amplification, and deletion in human cancers are depicted in the graph. Data were obtained from the cBioPortal for Cancer Genomics (//www.cbioportal.org/). We analyzed 10,259 samples from 9,682 patients with 25 different cancers from the Cancer Genome Atlas. (b) The types and frequencies of missense, in-frame and truncating mutations of CCND1 observed with regards to the cyclin D1 protein structure are shown.
