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. 2019 Dec 10;7(1):1699375. doi: 10.1080/23723556.2019.1699375

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Figure 1. — Hippo pathway effectors, YAP/TAZ, integrates various environmental cues and regulates ferroptosis through affecting the expression of different tissue-specific target genes. In response to various non-genetic environmental cues, Hippo pathway effectors, YAP/TAZ, regulates ferroptosis by affecting the expression of different sets of tissue-specific targets genes encoding lipid/iron metabolism and ROS production by NOXs (YAP1: Yes-associated protein 1; TAZ: transcriptional coactivator with PDZ-binding motif; TF: transcriptional factor(s); RCC: renal cell carcinoma; OVCA: ovarian cancer; ROS: reactive oxygen species; NOX: NADPH Oxidase; ACSL4: encoding acyl-CoA synthetase long-chain family member 4; TFRC: encoding transferrin receptor; EMP1: encoding epithelial membrane protein 1; ANGPTL4: encoding angiopoietin-Like 4).