Table 1.
Correlation analysis of HDACi sensitivity and DHRS2 expression in adherent cells from the ovary. Pearson correlation coefficients for comparisons of HDAC inhibitor sensitivity data, expressed as the area under concentration-response curves (AUCs), with DHRS2 expression measurements, expressed as log2 robust-multi-array-average values.
| Compound | Correlation | Target |
|---|---|---|
| Apicidin | −0.260 | HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 |
| SAHA | −0.201 | HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 |
| Belinostat | −0.447 | HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 |
| Panobinostat | −0.258 | HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 |
| Entinostat | −0.133 | HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 |
| ISOX | −0.0554 | HDAC6 |
| Tubastatin A | −0.221 | HDAC6 |
| BRD-A94377914 | −0.171 | HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 |
| Merck 60 | −0.187 | HDAC1, HDAC2 |
| BRD-K80183349 | −0.195 | HDAC1, HDAC2, |
| BRD-K24690302 | −0.158 | HDAC1 |
* Pearson correlation coefficients between HDAC inhibitors sensitivity data, expressed as areas under concentration-response curves (AUCs), with DHRS2-expression measurements, expressed as log2 robust-multi-array-average values.