Table 3.

Mendelian Randomization examining causal CpGs and miRNAs for age at menarche.

	MR: CpG–>Trait (Perry JR, et al. Nature 2014)			MR: CpG–>Trait (Nealelab, UKBiobank)			Reverse MR: Trait–>CpG (Perry JR, et al. Nature 2014)				MR: miRNA–>Trait (Perry JR, et al. Nature 2014)
CpG	meQTLs	Beta	Pval	meQTLs	Beta	Pval	GWAS SNPs	Beta	Pval	miRNA	miR-eQTLs	Beta	Pval
cg05730092	10	−0.94	5.34E-06	15	−0.23	6.82E-04	86	−0.03	0.09	miR-382-5p	13	−0.02	1.15E-03
										miR-127-3p	15	−0.02	0.05
cg13521842	7	−0.86	5.22E-04	15	−0.19	6.11E-03	86	−0.02	0.15	miR-127-3p	15	−0.02	0.05
cg13583544	7	−2.77	1.58E-04	11	−0.76	7.25E-04	86	−0.01	0.08
cg13673514	6	−0.87	9.22E-04	10	−0.19	0.03	86	−0.02	0.17	miR-127-3p	15	−0.02	0.05
cg26279372	8	−0.94	1.16E-04	16	−0.21	2.94E-03	86	−0.03	0.10	miR-127-3p	15	−0.02	0.05
cg18089426	8	0.25	0.02	18	0.07	0.02	86	0.01	0.61	miR-411-3p	7	−0.05	6.09E-07
										miR-382-5p	13	−0.02	0.00
										miR-127-3p	15	−0.02	0.05
cg07957069	9	−0.58	6.41E-04	16	−0.13	0.02	86	−0.01	0.27	miR-127-3p	15	−0.02	0.05
cg18684879	8	1.06	6.70E-03	14	0.20	0.06	86	2.32E-03	0.44
cg18125510	6	−1.80	1.25E-04	10	−0.23	0.07	86	−0.01	0.16

* cg05730092, cg13521842, cg13583544, cg13673514, and cg26279372 were at r²> 0.2; cg18089426, cg07957069 and cg18684879 were at r² > 0.2.