Figure 1.

Pipeline to determine novel lncRNA biomarkers of drug response. Using the lncRNA transcriptome and drug response profiles of cell lines, we construct prediction models for each individual drug (y) as a function of lncRNA expression (β_jx_j) and other potential confounding variables, including cis-protein-coding genes (β_kx_k) and tissue-type (β_T). Intercept and unexplained variance are denoted by β₀ and ϵ_i respectively. Thus, we determined statistically significant novel biomarkers that could be candidates for further experimental validation.