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. 2019 Aug 7;15(1-2):61–71. doi: 10.1080/15592294.2019.1649527

Figure 1.

Figure 1.

HFD associates with reversible hepatic steatosis and transcriptional derangement. (a) HFD induces weight gain. Data analysed by repeated measures two-way ANOVA with Tukey post hoc testing for multiple comparisons **p < 0.01 for HFD versus CON. (b) HFD was associated with an increase in hepatic steatosis score, assessed through the application of the NAS system. Data analysed by Kruskal Wallis test with Dunn’s post hoc test for multiple comparisons **p < 0.01 for HFD versus CON. (c) Volcano plot of CON and HFD liver showing up- (red) and downregulated (blue) transcripts (adjusted p < 0.05 (Benjamini-Hochberg) and change >10%). (d) qPCR of cholesterol synthesis mediators in CON, HFD, HFD-reversal and CON-reversal (n = 10/group) *p < 0.05, **p < 0.01 versus CON.