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. 2019 Aug 7;15(1-2):61–71. doi: 10.1080/15592294.2019.1649527

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — HFD associates with reversible genic 5hmC enrichment at discrete genes with biological relevance. (a) Scatter plot of changes in genic 5hmC versus transcriptional change; Δ5hmC = difference in mean number of normalised reads/150bp window. (b) Z-score heatmap analysis with hierarchical clustering based on average gene body 5hmC for (i) all genes (ii) top 10 induced and (iii) top 10 suppressed genes. (c) hmeDIP-qPCR validation of differentially hydroxymethylated loci and resolution in HFD-reversal group. Data are fold change versus CON analysed by one way Anova with Tukeys test for multiple comparisons * = p < 0.05.