Figure 5.

Overexpression of circDENND2A reduced oxygen glucose deprivation (OGD) injury by downregulating microRNA (miR)-34a in H9c2 cells.

(a) While miR-34a mimic was transfected into circDENND2A-induced cells, miR-34a expression was markedly enhanced, (b) cell viability was declined. (c) Cell apoptosis rate and (d) levels of Bax and Cleaved-Caspase-3 were meaningfully enhanced (Figure 5d). Besides, (e) the migration cells and (f) levels of matrix metalloproteinase (MMP)-2 and MMP-9 were meaningfully declined. *P < 0.05; **P < 0.01; ***P < 0.001