Figure 4.

18S and 5S rDNA copy number changes as a function of breast cancer genetic subtype. (a) Differences in 18S rDNA copy numbers between paired tumour and non-tumour samples as a function of categorical grouping of Estrogen Receptor Negative (ER-) and Positive (ER+), and Progesterone Receptor (PR). Data from Figure 3(c). (b) As in (a), but with 5S rDNA. (c) As in (a), but categorically grouped by Her2 expression phenotype. Grades 0–1+ were called ‘negative’ and 2–3+ were called ‘positive.’ (d) as in (e), but with 5S rDNA. (e) Differences in 18S (blue) and 5S (green) rDNA copy numbers between paired tumour and non-tumour samples as a function of Ki-67 expression, R² (18S) = 0.003, R² (5S) = 0.001. Data and S.E.M. are from Figure 3(c).