Figure 8.

Tauroursodeoxycholic acid (TUDCA) reduces fibrotic responses in idiopathic pulmonary fibrosis lungs cultured ex vivo. (A and B) Representative Western blot (A) and quantitative analysis (B) show that TUDCA (500 μM) reduces expression of endoplasmic reticulum stress and mesenchymal and apoptotic markers with a trend toward reduction of senescence markers in idiopathic pulmonary fibrosis lung slices after 5 days of treatment in ex vivo culture. Each lane represents one slice from the same lung. n = 4 lungs for endoplasmic reticulum stress and mesenchymal and apoptotic markers; n = 3 for senescence markers with and without TUDCA. Paired t test: *P < 0.05.