Table 1.
Protease Functions and Redundancy in Cystic Fibrosis Lung Disease
| Function | Protease Class Involved | References |
|---|---|---|
| Matrix degradation | Serine, cysteine, MMP | 52, 54, 55, 70 |
| Cytokine processing | Serine, cysteine, MMP | 14, 18, 46, 56 |
| Cytokine upregulation | Serine, cysteine, MMP | 15, 48, 54, 55 |
| PAR activation | Serine, cysteine, MMP | 48, 71 |
| Trans-class protease activation | Serine, cysteine | 9, 12, 26, 27 |
| Host defense protein degradation (including antiproteases) | Serine, cysteine | 21–23, 29, 42–45 |
| ENaC activation | Serine, cysteine | 38, 49, 50 |
| CFTR degradation | Serine | 37 |
| Mucus modulation | Serine | 33–36, 48 |
| Iron liberation | Serine | 24, 25 |
Definition of abbreviations: CFTR = cystic fibrosis transmembrane conductance regulator; ENaC = epithelial sodium channel; MMP = matrix metalloprotease; PAR = protease-activated receptor.