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. 2020 Feb 1;11(1):1–16. doi: 10.14336/AD.2019.0507

Figure 2.

Figure 2.

Gene expression in the PFC of focal ischemic stroke mice. (A-C) In the ipsilateral PFC of the animals with stroke for 8 weeks, qPCR data suggested the mRNA level of NR1 and NR2A were significantly reduced (A, Sham: n = 5, Stroke: n = 5), which is consistent with the western blot results (B-C, Sham: n = 4, Stroke: n = 4). The mRNA level of GluR1 was significantly increased (A), although no significant difference was detected in the protein expression level of GluR1 (B-C) (*P < 0.05, **P < 0.01, ***P < 0.001; Student’s t-test). (D-F) In the western blot assessment, compared to the animals in the sham group, the protein expression levels of MBP, PSD95, oxytocin, oxytocin R, BDNF, DAT, and TH were significantly reduced in PFC of stroke animals. Arrows point to the bands of PSD95 and DAT; the two GAD65/67 bands were used in the quantification. (Sham: n = 4, Stroke: n = 5; *P < 0.05, **P < 0.01; Student’s t-test).