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. Author manuscript; available in PMC: 2020 Jan 15.
Published in final edited form as: Science. 2018 Jun 21;361(6400):eaar2555. doi: 10.1126/science.aar2555

Fig. 6. A model for functional LCD-LCD interactions in vivo: From hubs to phase separation.

Fig. 6.

(A) Dynamic and sequence-specific LCD-LCD interactions drive hub formation in live cells. (B) LCD-dependent transactivation occurs in hubs formed over a broad range of TF concentrations. At endogenous concentrations, TF LCDs form transactivation hubs at native genomic loci without undergoing evident phase separation. Upon TF LCD overexpression, phase separation is observed at synthetic TF binding site arrays.

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