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. Author manuscript; available in PMC: 2020 Nov 15.
Published in final edited form as: Bioorg Med Chem. 2019 Sep 13;27(22):115121. doi: 10.1016/j.bmc.2019.115121

Figure 3. Propylamycin binding to bacterial A-site RNA construct.

Figure 3.

(A) Changes in volume-corrected fluorescence intensity (Fcorr) upon titration with paromomycin, 4′-O-ethylparomomycin, and propylamycin are shown. (B) Representative binding curves of fraction bound (Fr) as a function of paromomycin, 4′-O-ethylparomomycin, and propylamycin concentration fitted to Equation 3 are overlaid (R2 = 0.99, 0.97, and 0.95, respectively).