. Author manuscript; available in PMC: 2020 Nov 15.

Published in final edited form as: Bioorg Med Chem. 2019 Sep 13;27(22):115121. doi: 10.1016/j.bmc.2019.115121

Table 2.

Selectivity of AG translation inhibition potential and binding affinity of A-site RNAs

Aminoglycosides	Selectivity for bacterial over mt A site
	ratio (wt-mt/wt-bac)		ratio (mut-mt/wt-bac)
	IC₅₀	K_d	IC₅₀	K_d
neomycin	200	1100	20	100
paromomycin	1700	1300	200	560
4′-O-ethylparomomycin	1212	427	1500	287
propylamycin	5566	13450	1733	2900