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Gene silencing cuboplexes. A) Luciferase gene knockdown in HeLa-Luc cells of cuboplexes (green bar) and lipoplexes (red bar) at different charge ratios. For cuboplexes, the maximum knockdown efficiency was of 73.6% versus 35.8% from lipoplexes. B) Membrane integrity test of HeLa-Luc cells when incubated with cuboplexes and lipoplexes. C) Representative Cryo-EM images of a lipoplex and a cuboplex. Reprinted with permission from [19]. Copyright 2018 American Chemical Society.
