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. 2020 Jan 15;40(3):585–604. doi: 10.1523/JNEUROSCI.1626-19.2019

Figure 9.

Figure 9.

Comparison of orientation/direction tuning properties of dLGN boutons versus V1 L2/3 neurons. A, B, Control data only. A, Raincloud plots represent distributions of global orientation selectivity index (gOSI) values in binocular, contra-only, and ipsi-only boutons (left) and V1 L2/3 neurons (right). V1 L2/3 neurons are more orientation-selective than dLGN boutons. Linear mixed-effects models. Boutons versus L2/3 neurons: F = 10.85, p = 2 × 10−5; boutons: binocular versus contra-only: F = 2.98, p = 0.08; binocular versus ipsi-only: F = 44.28, p = 7 × 10−11; contra-only versus ipsi-only: F = 15.25, p = 9 × 10−5. V1 L2/3 neurons: binocular versus contra-only: F = 23.98, p = 1 × 10−6; binocular versus ipsi-only: F = 9.91, p = 0.001; contra-only versus ipsi-only: F = 1.41, p = 0.23. B, Distributions of global direction selectivity index (gDSI) values in binocular, contra-only, and ipsi-only boutons and V1 L2/3 neurons (same convention as A). dLGN boutons are more direction-selective than V1 L2/3 neurons. Linear mixed-effects models: Boutons versus L2/3 neurons: F = 15.90, p = 1 × 10−7; boutons: binocular versus contra-only: F = 0.12, p = 0.72; binocular versus ipsi-only: F = 8.23, p = 0.004; contra-only versus ipsi-only: F = 34.46, p = 5 × 10−9. V1 L2/3 neurons: binocular versus contra-only: F = 23.53, p = 1 × 10−6; binocular versus ipsi-only: F = 6.42, p = 0.01; contra-only versus ipsi-only: F = 1.31, p = 0.25. C, Violin and overlaid box plots of gOSI in dLGN boutons (left) and V1 neurons (right) in control versus MD mice. Linear mixed-effects models. Boutons: effect of MD: F = 1.01, p = 0.33; binocular versus contra-only: F = 1.96, p = 0.16; binocular versus ipsi-only: F = 41.71, p = 1 × 10−10; contra-only versus ipsi-only: F = 43.59, p = 4 × 10−11. V1 L2/3 neurons: effect of MD: F = 0.95, p = 0.34; binocular versus contra-only: F = 32.54, p = 1 × 10−8; binocular versus ipsi-only: F = 11.44, p = 0.0007; contra-only versus ipsi-only: F = 2.81, p = 0.09. D, Violin and overlaid box plots of gDSI in dLGN boutons (left) and V1 neurons (right) in control versus MD mice. Linear mixed-effects models. Boutons: effect of MD: F = 1.37, p = 0.26; binocular versus contra-only: F = 0.0009, p = 0.97; binocular versus ipsi-only: F = 11.38, p = 0.0007; contra-only versus ipsi-only: F = 44.76, p = 2 × 10−11. V1 L2/3 neurons: effect of MD: F = 1.03, p = 0.32; binocular versus contra-only: F = 50.41, p = 1 × 10−12; binocular versus ipsi-only: F = 3.38, p = 0.06; contra-only versus ipsi-only: F = 14.25, p = 0.0001. In box plots, middle mark indicates the median, and bottom and top edges indicate 25th and 75th percentiles, respectively. All panels: n = 2866 boutons in 5 control mice, 3503 boutons in 6 MD mice; 1051 V1 L2/3 neurons in 9 control mice, 1355 L2/3 neurons in 6 MD mice. ns, Not significant at p > 0.1. †p < 0.1, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.