Figure 8.

Model of neurotransmitter plasticity in the DRv in response to chronic social stress. In response to chronic social stress, neurotransmitter plasticity occurs in the DRv of stressed rats. Rats susceptible to stress-induced anhedonia gain TPH2 and lose VGLUT3, whereas resilient rats only lose VGLUT3. Loss of VGLUT3 leads to lower coexpression of the two markers in both conditions. The plasticity occurs in neurons expressing Pet1 transcripts. Activation of CRH+ neurons of the CeA promotes resilience and blocks susceptibility.