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. 2019 Dec 5;4(23):e130090. doi: 10.1172/jci.insight.130090

Figure 5. T cell activation is associated with lower mycobacterial antigen–specific immune response following immunization with MVA85A.

Figure 5

(A and B) The D28 IFN-γ ELISpot response to Ag85A was inversely correlated with both activated CD4+ T cell (A) and activated CD8+ T cell (B) frequency. (C) There was a trend for lower anti–Ag85A IgG in CMV+ compared with CMV– infants following immunization with MVA85A. (D) Anti–Ag85A IgG was inversely correlated with CMV ELISpot response. Mann Whitney U test and Spearman’s rho correlation. Red, cases; gray, controls.