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. Author manuscript; available in PMC: 2020 Jan 15.
Published in final edited form as: Mol Cell. 2019 Mar 13;73(6):1097–1114. doi: 10.1016/j.molcel.2019.02.007

Figure 3. N-terminal processing of actin.

Figure 3

In eukaryotes, the Class I actins, β- and γ-actin, match the substrate specificity of NatB and are co-translationally Nt-acetylated by NatB. This acetylated methionine is next cleaved off probably by the enzymatic action of an unidentified aminopeptidase. The newly exposed N-terminus is post-translationally Nt-acetylated by NatH/NAA80. These post-translational steps are specific for animals. The Class II actins, muscle α- and γ-actin, likely undergo co-translational NatA-mediated Nt-acetylation after iMet removal and then follow the same post-translational processing as the Class I actins.