Table 1.
Selected original research articles and reviews supporting the involvement of the prolactin/vasoinhibin axis in preeclampsia.
| Brief description | Year | References |
|---|---|---|
| Original research articles | ||
| Point mutations in vasoinhibin precursors might impact vasoinhibin generation in PE | 2017 | (14) |
| Circulating vasoinhibin alters blood pressure in mice | 2016 | (15) |
| Higher circulating vasoinhibin levels and higher activity of cathepsin D in sera from patients with PE | 2015 | (16) |
| Urinary PRL concentrations and the presence of vasoinhibin are associated with the severity of PE | 2013 2008 |
(17, 18) |
| Vasoinhibin is increased in the circulation, urine, and amniotic fluid of preeclamptic women and may contribute to endothelial cell dysfunction and low birth weight | 2007 | (19) |
| Plasma PRL levels are raised in pregnant women with pre-eclamptic features | 1975 | (11) |
| Reviews/Hypotheses | ||
| Hypothesis that vasoinhibin generation by matrix metalloproteases at the feto-maternal interface may contribute to PE | 2010 | (20) |
| Hypothesis that excessive placental vasoinhibin generation may contribute to PE | 2002 | (21) |
| Hypothesis that prolactin might be involved in the aetiopathology of PE | 1975 | (12) |