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Establishment of high-fat-diet-induced obesity. WT, caspase-1/11−/− and Nlpr3−/− mice were fed SFD (17% fat) or HFD (45% fat) for 90 days. The weight gain curve was fitted with the weekly weighing of the animals (A,C). Weight of the animals at the final of treatment (B,D) and abdominal fat (E). ANOVA test was applied, the bars representing confidence interval of 95% (****p < 0.0001).
