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. 2020 Jan 9;10:2957. doi: 10.3389/fimmu.2019.02957

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Copyright © 2020 Deng, Pan, Alam, Liang, Wu, Liu, Mor-Vaknin, Duan, Williams, Tian, Zhang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The CitH3 mAb (4 Cit) ameliorates acute lung injury in lethal endotoxic shock. Mice were randomly divided into four groups: (1) IgG only (20 mg/kg), (2) LPS (20 mg/kg) + IgG (20 mg/kg), (3) LPS + CitH3 mAb (4 Cit) (20 mg/kg), and (4) LPS + CitH3 mAb (3 Cit) (20 mg/kg) (n = 3/group). Blood and organs were harvested at 12 h after LPS injection. (A) Representative hematoxylin and eosin staining of mouse lung sections is shown, and histological analysis of acute lung injury (ALI) was graded by a blinded pathologist and presented as ALI score (mean ± SEM, n = 3/group). White arrows indicate inflammatory changes. (B) IL-1β and TNF-α of lung homogenates were determined by ELISA. Cytokine levels were normalized by protein concentration and were significantly lower in CitH3 mAb (4 Cit)-treated mice (mean ± SEM, n = 3/group). *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. ns, non significance.