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. 2020 Jan 15;10:419. doi: 10.1038/s41598-019-57350-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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FAK supplementation decreases lung injury in mice challenged with 4 h of HMV. Representative images (IHC staining, 400×) and the relative semiquantitative analysis showing that FAK recombinant adenovirus (AF) injection enhanced the expression of FAK (A) and phospho-Akt (B) in AECs. The lung wet/dry ratio (C), BALF protein level (D), BALF cell counts (E) and RAGE level in the BALF (F) in the different groups of mice are shown. (G) Representative images (400×) of apoptosis in AECs, as visualised by TUNEL staining, and the quantification of the results. (H) Representative images (H&E, 400×) of lung tissue and the quantification of lung injury. FAK supplementation attenuated injury, inducing a decreased lung injury score and apoptosis index in lung tissues, as well as a lower protein level, RAGE level and cell counts in the BALF, whereas the protective effect of FAK was blocked by a FAK inhibitor. Lung injury was triggered by HMV, and mice received different treatments before HMV as follows: injection with vector only (vector); FAK recombinant adenovirus injection (AF), AF plus FAK inhibitor or DMSO. The data are presented as the mean ± SEM (*p < 0.05; **p < 0.01 by two-tailed t test).