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. 2020 Jan 9;10:3018. doi: 10.3389/fimmu.2019.03018

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Copyright © 2020 Shirai, Shibuya, Kawai, Tamiya, Munakata, Omata, Suzuki, Aoshi and Yoshioka.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hemagglutinin (HA)- and neuraminidase (NA)-specific antibody responses in vivo. Levels of HA from Cal7-specific total IgG (A), IgG1 (B), and IgG2c (C); of NA from Cal7-specific total IgG (D), IgG1 (E), and IgG2c (F); and of HA from PR8-specific total IgG (G), IgG1 (H), and IgG2c (I) in plasma were evaluated by using ELISA 7 days after final immunization. The same plasma samples as used in Figure 4 were used here. We used 800- (•), 4000- (■), and 20,000- (▴) fold diluted plasma samples for (A–F) and 32- (•), 160- (■), and 800- (▴) fold diluted plasma samples for (G–I). n = 5. Data are means ± SD. Significant differences were analyzed only in the 800-fold-diluted plasma samples (A–F) and the 32-fold-diluted plasma samples (G–I). ^†P < 0.05, ^††P < 0.01, ^†††P < 0.001, ^††††P < 0.0001 vs. group immunized with SV alone; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 as indicated by Tukey's test.