Table 1.
Clinical, serological, and pathological characteristics of the NAFLD patients.
| NAFL | NASH | P value | |
|---|---|---|---|
| N | 57 | 74 | |
| Male (%) | 68.4 | 43.2 | <0.01 |
| Age (Yr) | 48 ± 15 | 55 ± 15 | <0.01 |
| BMI (kg/m2) | 28 ± 4 | 30 ± 6 | NS |
| Plt (104/μL) | 22 ± 6 | 20 ± 7 | NS |
| Albumin (g/dL) | 4.4 ± 0.3 | 4.2 ± 0.4 | <0.01 |
| T-bil (mg/dL) | 0.8 ± 0.4 | 0.8 ± 0.3 | NS |
| AST (IU/L) | 50 ± 24 | 67 ± 38 | <0.01 |
| ALT (IU/L) | 93 ± 67 | 86 ± 64 | NS |
| ChE (U/L) | 379 ± 92 | 328 ± 121 | NS |
| γ-GTP (IU/L) | 97 ± 113 | 82 ± 59 | NS |
| AFP (ng/mL) | 2.4 ± 1.8 | 3.5 ± 2.7 | NS |
| TG (mg/dL) | 174 ± 83 | 158 ± 79 | NS |
| LDL-C (mg/dL) | 131 ± 29 | 114 ± 39 | <0.05 |
| HDL-C (mg/dL) | 50 ± 15 | 45 ± 16 | NS |
| HbA1c (%) | 5.9 ± 0.7 | 6.2 ± 1.8 | <0.001 |
| FBS (mg/dL) | 106 ± 26 | 123 ± 45 | <0.05 |
| IRI (μIU/L) | 20.0 ± 30.5 | 14.1 ± 11.1 | NS |
| HOMA-IR | 5.7 ± 9.3 | 4.5 ± 4.4 | <0.05 |
| cCK18 (U/L) | 572 ± 359 | 927 ± 698 | <0.01 |
| M2BPGi (COI) | 0.73 ± 0.66 | 1.24 ± 0.95 | <0.001 |
| FIB4 index | 1.55 ± 1.4 | 2.31 ± 1.53 | <0.001 |
| APRI | 0.60 ± 0.34 | 0.94 ± 0.69 | <0.001 |
| Pathological findings | |||
| Steatosis (0/1/2/3) | 0/23/22/12 | 0/23/30/21 | |
| Lobular inflammation (0/1/2/3) | 24/30/3/0 | 0/38/31/5 | |
| Ballooning (0/1/2) | 54/2/1 | 1/46/27 | |
| Fibrosis (0/1/2/3/4) | 30/27/0/0/0 | 2/37/10/23/2 | |
Data are presented as mean ± SD. P values correspond to the comparison between NAFL and NASH groups. Mann Whitney U tests for continuous factors and Fisher’s exact test for categorical factors were used. Abbreviations: NAFL, non-alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitis.