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. 2020 Jan 15;10:348. doi: 10.1038/s41598-019-57185-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Trabecular bone in the distal femur stained by TRAP in (A) male wild type (WT), (B) male Keap1 heterozygous (Ht), (C) female wild type (WT) and (D) female Keap1 heterozygous (Ht) mice, indicating osteoclast surface (Oc.S/BS) and osteoclast number (N.Oc/B.Pm). The osteoclast number and surface were significantly reduced in male Keap1-Ht mice compared to the WT mice. Serum CTX was significantly less in male Keap1 Ht mice than male WT mice. Data were tested using two-way ANOVA with Keap1 genotype and gender as main effects. The bar at the top of each graph indicates significance of the main effects and interaction (# = Keap1 genotype p < 0.05; @ = gender p < 0.05; $ = interaction p < 0.05). When at least one term was significant, t tests were conducted and is indicated as *p < 0.05 v.s. male WT mice. For Oc.S/BS and N.Oc/B.Pm, n = 10–14/group. For CTX, n = 10–13/group.