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. 2020 Jan 15;10:348. doi: 10.1038/s41598-019-57185-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Keap1 deficient mice exhibit increased bone mineralization in male Keap1^+/− newborn mice compared to WT newborn mice. Newborn pups were stained with Alcian blue/Alizarin red. Bone is stained red and cartilage blue. Neurocranium, limbs and spine were detected. Limbs showed accelerated skeletal mineralization in fingers and toes (black arrows) in Keap1 heterozygotes and knockout newborn mice in comparison with their wild type control.