Table 1.

Genes of the pyrimidine metabolism specifically upregulated in biofilm cells.

	Log2 (fold-change)
Gene ID	24 h	48 h	72 h	Function. Gene name	iTRAQ
BC0325	2.41	2.56	−4.27	Purine biosynthesis pathway. Adenylosuccinate lyase	*
BC0326	3.13	3.87	−0.69	Purine biosynthesis pathway. Phosphoribosylaminoimidazole-succinocarboxamide synthase	*
BC0327	3.09	3.37	−0.66	Purine biosynthesis pathway. Phosphoribosylformylglycinamidine synthase subunit PurS	*
BC0328	2.91	3.37	−0.80	Purine biosynthesis pathway. Phosphoribosylformylglycinamidine synthase I	*
BC0329	2.37	3.17	−1.16	Purine biosynthesis pathway. Phosphoribosylformylglycinamidine synthase II	*
BC0330	2.64	3.91	0.40	Purine biosynthesis pathway. Amidophosphoribosyltransferase	*
BC0331	2.96	3.52	−1.96	Purine biosynthesis pathway. Phosphoribosylaminoimidazole synthetase	*
BC0332	4.01	3.68	−1.38	Purine biosynthesis pathway. Phosphoribosylglycinamide formyltransferase	*
BC3882	3.66	−0.38	−0.07	Pyrimidine biosynthesis pathway. Orotate phosphoribosyltransferase	*
BC3883	3.73	0.65	0.84	Pyrimidine biosynthesis pathway. Orotidine 5'-phosphate decarboxylase
BC3884	4.14	1.06	1.54	Pyrimidine biosynthesis pathway. Dihydroorotate dehydrogenase 1B
BC3885	4.18	0.98	1.12	Pyrimidine biosynthesis pathway. Dihydroorotate dehydrogenase electron transfer subunit
BC3886	4.29	0.22	0.95	Pyrimidine biosynthesis pathway. Carbamoyl phosphate synthase large subunit	*
BC3887	3.40	1.19	0.66	Pyrimidine biosynthesis pathway. Carbamoyl phosphate synthase small subunit
BC3888	5.69	2.74	2.27	Pyrimidine biosynthesis pathway. Dihydroorotase
BC3889	4.87	1.78	0.26	Pyrimidine biosynthesis pathway. Aspartate carbamoyltransferase

Asterisk indicates confirmed behavior at protein levels