Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jan 15;10:305. doi: 10.1038/s41598-019-57246-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Effects of amiodarone on ionic currents/fluxes and consequent changes in heart rate. (A) Changes in heart rate when each ion current is reduced from 100% (green number) to x% (red number) in SAN cells. (B) Heart rate of sinus node dysfunction (SND) cells in the presence of amiodarone action on each target only. Inhibitions of I_CaL, I_CaT, I_f, I_Na, I_Kur and J_rel cause reductions in the heart rate, inhibitions of I_Ks have no effect on the heart rate, and inhibitions of I_Kr, I_to, I_f, I_NaK, I_NCX and J_up lead to increases in the heart rate. Group one (#1): I_CaL, I_CaT, I_f, I_Na, I_Kur and J_rel; group two (#2): I_Ks; and group three (#3): I_Kr, I_to, I_f, I_NaK, I_NCX and J_up. (C-D) Action potentials (APs) and the heart rate of SND cells in the presence of AMI action on targets in the group #1, #2 and #3. The Red star indicates heart arrest.