Skip to main content
. 2020 Jan 9;11:355. doi: 10.3389/fnagi.2019.00355

TABLE 3.

Full regression output including Beta, SE, and p-values for tested relationships, emboldened results are significant.

(A)
Unadjusted Educ-Occ Phys Act Cog Act CMC BMI HbA1c BDI Smoke CAGE
Risk × BR B SE p B SE p B SE p B SE p B SE p B SE p B SE p B SE p B SE p
GCC (FA) 0.00108 0.0007 0.1362 0.0008 0.0003 0.01780 –0.00025 0.0002 0.1744 −0.00347 0.0014 0.01060 –0.00023 0.0003 0.4138 –0.00153 0.0024 0.5255 –0.00026 0.0003 0.4312 −0.00683 0.0032 0.03520 –0.00512 0.0063 0.4148
PCC (FDG) 0.00481 0.0035 0.168 0.0046 0.0017 0.00620 0.00240 0.0009 0.00720 −0.03078 0.0064 0.00001 −0.00285 0.0014 0.03550 −0.04327 0.0112 0.00010 −0.00415 0.0016 0.01150 −0.03349 0.0157 0.03330 –0.00012 0.0304 0.9969
AD ROI (Thick) 0.00321 0.0024 0.19 0.0023 0.0012 0.0502 –0.00021 0.0006 0.7337 −0.02029 0.0045 0.00001 −0.00259 0.0010 0.00680 –0.00838 0.0081 0.3022 −0.00319 0.0011 0.00430 −0.03970 0.0108 0.00030 −0.05290 0.0211 0.01230
SupPar (Thick) 0.00255 0.0025 0.314 0.0001 0.0012 0.9613 0.00105 0.0006 0.1035 –0.00384 0.0047 0.4184 0.00173 0.0010 0.0809 –0.00654 0.0084 0.4353 –0.00069 0.0012 0.5499 −0.02731 0.0112 0.01550 −0.07410 0.0216 0.00070
ICV (Vol) 14.53234 3.1316 0.00001 1.7694 1.5417 0.2516 −2.21202 0.8103 0.00650 10.88245 5.9642 0.0686 –1.92489 1.2462 0.123 –6.35487 10.6098 0.5495 0.27990 1.4600 0.848 –1.28664 14.2745 0.9282 33.04846 27.5332 0.2305
Adjusted Educ-Occ Phys Act Cog Act CMC BMI HbA1c BDI Smoke CAGE
Risk × BR B SE p B SE p B SE p B SE p B SE p B SE p B SE p B SE p B SE p
GCC (FA) 0.00091 0.0007 0.2006 0.0007 0.0003 0.04770 –0.00012 0.0002 0.5285 –0.00242 0.0014 0.0806 –0.00019 0.0003 0.4906 –0.00112 0.0024 0.6352 –0.00035 0.0003 0.2799 −0.00621 0.0032 0.04990 –0.00543 0.0061 0.375
PCC (FDG) 0.00756 0.0033 0.02380 0.0045 0.0016 0.00580 0.00137 0.0009 0.1243 −0.02128 0.0064 0.00100 −0.00280 0.0013 0.03050 −0.03754 0.0108 0.00060 −0.00398 0.0016 0.01100 –0.02530 0.0150 0.0929 0.00935 0.0290 0.7475
AD ROI (Thick) 0.00323 0.0024 0.1867 0.0020 0.0012 0.0842 –0.00018 0.0006 0.7814 −0.01840 0.0047 0.00010 −0.00252 0.0009 0.00820 –0.00701 0.0081 0.3871 −0.00327 0.0011 0.00320 −0.03778 0.0108 0.00050 −0.05173 0.0210 0.01400
SupPar (Thick) 0.00336 0.0025 0.1797 –0.0001 0.0012 0.9073 0.00064 0.0007 0.3265 0.00214 0.0049 0.6606 0.00179 0.0010 0.0665 –0.00394 0.0083 0.6348 –0.00056 0.0011 0.6276 −0.02319 0.0111 0.03770 −0.06849 0.0213 0.00140
ICV (Vol) 9.67513 2.3652 0.00001 1.2796 1.1553 0.2685 1.08832 0.6315 0.0854 –2.91924 4.6813 0.5332 –1.81222 0.9321 0.0524 –14.39758 8.0080 0.0728 –1.13769 1.0918 0.2979 –13.81308 10.7057 0.1975 5.07107 20.6777 0.8064
(B)
Unadjusted GCC PCC AD ROI SupPar ICV
BR × Cog B SE p B SE p B SE p B SE p B SE p
Global 2.80062 0.9010 0.00200 0.9593 0.2262 0.00001 0.45760 0.2720 0.0931 0.44047 0.2621 0.0934 0.00003 0.0002 0.8902
Memory 1.08056 1.0296 0.2944 0.6980 0.2449 0.00460 0.23238 0.3054 0.4471 –0.11163 0.2964 0.7066 −0.00074 0.0002 0.00160
Attention 2.24928 0.8604 0.00920 1.0748 0.2169 0.00001 0.40709 0.2576 0.1146 0.63481 0.2478 0.01070 –0.00026 0.0002 0.1876
Language 2.02338 1.0206 0.04790 0.7009 0.2514 0.00550 0.14444 0.3050 0.636 0.29686 0.2955 0.3156 –0.00009 0.0002 0.7143
Visuospatial 3.60372 0.9785 0.00030 0.2285 0.2447 0.351 0.68096 0.2952 0.02150 0.63359 0.2838 0.02600 0.00129 0.0002 0.00001
Adjusted GCC PCC AD ROI SupPar ICV
BR × Cog B SE p B SE p B SE p B SE p B SE p
Global 2.11878 0.9084 0.02010 0.6834 0.2342 0.00370 0.37298 0.2730 0.1725 0.21459 0.2605 0.4104 0.00054 0.0003 0.04660
Memory 1.05430 1.0379 0.3102 0.4135 0.2547 0.25466 0.13757 0.3017 0.6486 –0.39130 0.2949 0.1851 –0.00013 0.0003 0.6776
Attention 1.93948 0.8550 0.02370 0.7098 0.2224 0.00150 0.22823 0.2487 0.3593 0.35902 0.2425 0.1393 0.00050 0.0003 0.0511
Language 1.86428 1.0403 0.0737 0.4275 0.2617 0.1031 0.05065 0.3040 0.8677 0.09951 0.2976 0.7382 0.00061 0.0003 0.0496
Visuospatial 2.36245 0.9787 0.01610 0.2611 0.2494 0.2955 0.52470 0.2874 0.0685 0.68476 0.2784 0.01420 0.00105 0.0003 0.00030
(C)
Unadjusted Educ-Occ Phys Act Cog Act CMC BMI HbA1c BDI Smoke CAGE
Risk × Cog B SE p B SE p B SE p B SE p B SE p B SE p B SE p B SE p B SE p
Global 0.13989 0.0143 0.00001 0.0274 0.0074 0.00020 0.02990 0.0037 0.00001 −0.06770 0.0287 0.01880 −0.01272 0.0060 0.03440 0.01142 0.0505 0.8211 −0.02037 0.0069 0.00350 −0.39435 0.0668 0.00001 –0.06607 0.1332 0.62
Memory 0.10201 0.0168 0.00001 0.0155 0.0084 0.0655 0.02460 0.0043 0.00001 –0.03664 0.0326 0.2615 –0.01009 0.0067 0.1349 0.00809 0.0568 0.8868 −0.02636 0.0079 0.00080 −0.32235 0.0763 0.00001 –0.29116 0.1487 0.0508
Attention 0.09022 0.0142 0.00001 0.0233 0.0070 0.00100 0.02630 0.0036 0.00010 −0.09937 0.0271 0.00030 –0.01030 0.0057 0.0706 –0.01955 0.0485 0.6868 −0.02044 0.0066 0.00200 −0.33217 0.0638 0.00001 –0.06403 0.1271 0.6147
Language 0.14679 0.0162 0.00001 0.0260 0.0083 0.00180 0.03322 0.0042 0.00001 –0.04264 0.0324 0.189 −0.01393 0.0067 0.03850 0.00327 0.0574 0.9546 –0.01463 0.0079 0.0638 −0.35482 0.0759 0.00001 –0.00463 0.1482 0.14823331
Visuospatial 0.11419 0.0161 0.00001 0.0189 0.0081 0.01940 0.01202 0.0043 0.00500 –0.01840 0.0314 0.5581 –0.00248 0.0066 0.7058 0.05340 0.0549 0.3309 –0.00166 0.0076 0.8283 −0.26879 0.0740 0.00030 0.06110 0.1455 0.6747
Adjusted Educ-Occ Phys Act Cog Act CMC BMI HbA1c BDI Smoke CAGE
Risk × Cog B SE p B SE p B SE p B SE p B SE p B SE p B SE p B SE p B SE p
Global 0.14417 0.0138 0.00001 0.0251 0.0072 0.00050 0.03064 0.0038 0.00001 –0.02388 0.0295 0.4185 −0.01250 0.0058 0.03270 0.03165 0.0494 0.5221 −0.02046 0.0068 0.00270 −0.36405 0.0655 0.00001 –0.02553 0.1302 0.8446
Memory 0.11046 0.0164 0.00001 0.0144 0.0082 0.0808 0.02132 0.0044 0.00001 0.00635 0.0335 0.8497 –0.00985 0.0066 0.1361 0.02933 0.0558 0.5996 −0.02483 0.0077 0.00140 −0.29354 0.0752 0.00010 –0.24288 0.1461 0.0969
Attention 0.09696 0.0136 0.00001 0.0237 0.0068 0.00050 0.02472 0.0035 0.00001 –0.05286 0.0275 0.0551 –0.01014 0.0054 0.0621 0.00615 0.0464 0.8948 −0.02001 0.0063 0.00160 −0.29355 0.0615 0.00001 –0.06364 0.1248 0.6102
Language 0.15326 0.0160 0.00001 0.0248 0.0082 0.00270 0.03292 0.0043 0.00001 –0.00844 0.0337 0.8024 −0.01367 0.0066 0.04000 0.02159 0.0569 0.7046 –0.01386 0.0078 0.0765 −0.33347 0.0755 0.00001 0.02981 0.1469 0.8393
Visuospatial 0.10693 0.0156 0.00001 0.0160 0.0078 0.04080 0.01919 0.0042 0.00001 –0.00635 0.0317 0.8412 –0.00167 0.0063 0.7926 0.05236 0.0532 0.3254 –0.00468 0.0074 0.5271 −0.26906 0.0716 0.00020 0.03224 0.1407 0.8189

Results from unadjusted analyses and analyses adjusted for age, sex, and APOE4-status are provided. (A) Protective/Risk Factors × Brain Reserve Measures, (B) Brain Reserve Measures × Cognitive Measures, (C) Protective/Risk Factors × Cognitive Measures. Bold values denote statistical significance at a threshold of p < 0.05.