Table 2.

Studies included in the systematic review not included in the meta-analysis due to insufficient data or non-normal ovarian function control group

Author, year [ref], country	Title	Type of study	Objective of the study	Questionnaire	Sample size/observation group (age range) and population	Control group(size) and population	NOS
Pang 2006 [46], Chinaa	The demonstration study of the relationship between the social/psychology factors in patients with POF	Cross-sectional study	To study the relationship between premature ovarian failure and psychosocial factors such as emotional state, personality characteristics and negative life events	1. TABP/TCBP (reported 2007) 2. STAI 3. Life Events Scale	N = 80 33.3 ± 5.33 years Hospital-based	PCOS N = 60 25.6 ± 4.7 years, Normal N = 200 33.53 ± 5.29 years Population-based Insufficient data reported	8 High
Davis et al. 2010 [51], USA	The psychosocial transition associated with spontaneous 46, XX primary ovarian insufficiency: illness uncertainty, stigma, goal flexibility, and purpose in life as factors in emotional health	Cross-sectional and case–control study	To examine factors associated with emotional well-being in women with spontaneous primary ovarian insufficiency	1. CES-D 2. STAI 3. PANAS 4. Purpose in Life	N = 99 32.4 ± 5.2 years Hospital-based	Healthy control women of similar age N = 60 31.0 ± 6.9 years Population-based Insufficient data reported	7 High
Orshan et al. 2009 [53], USA	Women with spontaneous 46, XX primary ovarian insufficiency (hypergonadotropic hypogonadism) have lower perceived social support than control women	Cross-sectional study	To test the hypothesis that women with spontaneous POI differ from controls regarding perceived social support and to investigate the relationship with self-esteem	1. PRQ85 2. Rosenberg’s Self Esteem Questionnaire	N = 154 32.2 ± 4.9 years Hospital-based	Control women: healthy, free of chronic disease, not pregnant, and regularly menstruating N = 63 29.9 ± 7.0 years Population-based Insufficient data reported	7 High
Gibson-Helm et al. 2014 [48], Aus	Symptoms, health behavior and understanding of menopause therapy in women with premature menopause	Cross-sectional study	To explore symptoms, understanding of menopausal therapies, medication use and health-related behavior in women with and without premature menopause	GCS	N = 25 36 ± 8.0 years Population-based	Premenopausal women N = 23, 29 ± 13 years and women with medically induced premature menopause (MIPM)N = 29 38 ± 4.0 years Population-based	6 Medium
Schmidt et al. 2011 [49], USA	Depression in Women with Spontaneous 46, XX Primary Ovarian Insufficiency	Cross-sectional study	To characterize the prevalence of psychiatric disorders and the onset timing of clinically significant depression relative to POI and the onset of menstrual irregularity in women with POI	[DSM-IV] (SCID)	N = 174 31.6 ± 5.3 years Hospital-based	Turner syndrome N = 100 no description of age range Hospital-based	3 Low

^aEnglish translations of the Chinese abstracts are included as Online Resources ESM_4