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. 2020 Jan 9;10:1538. doi: 10.3389/fphar.2019.01538

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Copyright © 2020 Jiao, Wang, Ren, Sun and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NSA improves the recovery of SCI and the survival of neurons. (A) HE staining results of the sham, SCI and SCI+NSA group. Treated with 5 mg/kg NSA 15 min after SCI, NSA significant protective effect with less necrosis, karyopyknosis, infiltrated macrophages compared with the SCI group, scale bar = 50 μm. (B) NeuN/TUNEL staining results of the sham, SCI and SCI+NSA group, scale bar = 20 μm. Analysis of the positive neurons of the TUNEL staining results. *p < 0.05 vs. the sham group, ^# p < 0.01 vs. the SCI group. n = 5. SCI, spinal cord injury; NSA, necrosulfonamide; TUNEL, terminal deoxynucleotidyl transferase-dUTP nick end labeling.