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Synthesis and target validation of GA probe. (A) Synthetic route and structure of the GA probe used in the study. (B) Molecular docking results of GA with multiple proteins. (C) Immunofluorescence co-localization of GA probe and JNK1. (D) N-STORM picture of GA probe bound with JNK1. (E) Biacore analysis revealed that GA can bind well with JNK1. (F) Image of molecular dynamics simulation visualizes the combination of GA with JNK1.
