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. 2020 Jan 9;9:1431. doi: 10.3389/fonc.2019.01431

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Copyright © 2020 Cai, Bi, Bai, Zhang, Zhai, Xiao, Tang, Yang, Zhang, Li, Yang, Liu, Chen, Sun, Liu and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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JNK1 can aggravate the degree of malignancy of HCC. (A) Representative IHC images of JNK1 in normal tissues and tumors downloaded from the Human Protein Atlas (one-way ANOVA; ^**P < 0.01). (B) Statistical analysis of JNK1 expression level in normal tissues and tumors downloaded from TCGA database (one-way ANOVA; ^**P < 0.01). (C,D) Statistical analysis of JNK1 expression level in liver hepatocellular carcinoma (LIHC) based on clinical stage and AFP level (one-way ANOVA; ^*P < 0.05, ^***P < 0.001). (E) Survival curve analysis based on low and high JNK1 expressions in LIHC samples. (F) GO and KEGG enrichment analysis of JNK1-positive genes.