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. 2020 Jan 15;11:293. doi: 10.1038/s41467-019-14109-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — In HSV-1-infected cells, ICP27 interacts with CPSF and induces the assembly of an aberrant 3′ processing complex. At viral PASs or host PASs that have GC-rich upstream sequences (UPS), ICP27 binds to these UPS sequences and promotes recruitment of CPSF, thereby activating mRNA 3′ processing. The transition of ICP27 between the CPSF-bound and UPS RNA-bound states is illustrated by a dotted line.