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. 2020 Jan 15;10:343. doi: 10.1038/s41598-019-57018-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mass spectrometry and pathway analysis of Exo-WT, Exo-C and Exo-1537S proteins. (A) Venn diagram of proteins identified in exosomal preparations. (B) Gene ontology (GO) enrichment analysis of proteins only found in Exo-1537S (27 proteins) in which the top 8 significantly-enriched GO categories are indicated under “Cellular process”. (C) Gene ontology (GO) enrichment analysis of Exo-1537S proteins in which the 8 significantly enriched GO categories under “Cellular process” (depicted in B) are indicated (left panel). The list (right panel) shows several protein candidates representing each enriched category. (D) Gene ontology (GO) enrichment analysis of Exo-WT and/or Exo-C proteins (159 proteins) showing the top 10 significantly-enriched GO categories under “Cellular process”. (E) Gene ontology (GO) enrichment analysis of Exo-WT and/or Exo-C proteins showing the 14 significantly enriched GO categories under “Cellular process” (depicted in D). The list (right panel) shows several protein candidates associated to cancer progression identified in each category. (F) Western blot analysis of invasion-promoting protein candidates VE-Cadherin and Lactadherin, obtained from the proteomic analysis. Results from a representative experiment are shown. Hsp60 was included as a negative control; Hsp90 and Tsg101 were used as positive markers (n = 3).