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. 2020 Jan 15;10:356. doi: 10.1038/s41598-019-57114-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Naïve, memory and senescent T-cell subset changes On-treatment with FTY compared to Pre-treatment. Frequencies of naïve, memory and senescent T-cell subsets within total CD4 + and CD8 + T cells were compared in pre- and on-treatment samples using paired t-tests (A–K). Combined down-sampled data from nine patients’ matched pre- and on-treatment samples was analysed using viSNE, gating on CD3 + T cells. Relative expression of each marker within the total CD3 + population is shown in the heatmap (L), which displays the fold-change of each marker relative to the lesser of the two time points. viSNE plots (tSNE1 and tSNE2 plotted on x and y axes respectively) coloured by each marker (M) show the treatment-induced changes in the expression of these molecules across the CD4 + and CD8 + clusters.