Table 3.
Changes in major T-cell subset absolute counts On-treatment versus Pre-treatment with FTY.
| Cell subset | Pre mean (SD) | On mean (SD) | Change (On – Pre) | p value (unadjusted) | p value (adjusted) | |
|---|---|---|---|---|---|---|
| Naïve and memory T cells | CD4+ TN | 422 (268) | 4 (8) | −418 | <0.0001 | <0.0059 |
| CD4+ TCM | 357 (185) | 11 (15) | −346 | <0.0001 | <0.0059 | |
| CD4+ TEM | 257 (165) | 43 (71) | −214 | <0.0001 | <0.0059 | |
| CD4+ TEMRA | 22 (20) | 4 (5) | −18 | <0.0001 | <0.0059 | |
| CD8+ TN | 158 (122) | 4 (4) | −155 | <0.0001 | <0.0059 | |
| CD8+ TCM | 41 (62) | 4 (4) | −37 | 0.0021 | ns | |
| CD8+ TEM | 139 (85) | 61 (93) | −78 | 0.0001 | 0.0059 | |
| CD8+ TEMRA | 73 (80) | 49 (61) | −23 | 0.0031 | ns | |
| Cytokine-expressing T cells | CD4+ IFNγ+ | 135 (84) | 21 (41) | −114 | <0.0001 | <0.0059 |
| CD4+ GM-CSF+ | 123 (72) | 8 (10) | −115 | <0.0001 | <0.0059 | |
| CD4+ IL-17+ | 6 (4) | 0 (0) | −6 | <0.0001 | <0.0059 | |
| CD4+ IL-22+ * | 11 (8) | 1 (1) | −11 | <0.0001 | <0.0059 | |
| CD4+ IL-4+ * | 30 (19) | 2 (2) | −28 | <0.0001 | <0.0059 | |
| CD4+ IL-10+ | 9 (8) | 1 (1) | −8 | <0.0001 | <0.0059 | |
| CD8+ IFNγ+ | 147 (93) | 89 (103) | −58 | 0.0006 | 0.0354 | |
| CD8+ GM-CSF+ | 37 (34) | 10 (10) | −27 | <0.0001 | <0.0059 | |
| CD8+ IL-17+ | 2 (1) | 2 (3) | 0 | ns | ns | |
| CD8+ IL-4+ | 12 (14) | 3 (3) | −9 | 0.0003 | 0.0177 | |
| RTE & Senescent T cells | CD4+ RTE | 393 (246) | 6 (8) | −387 | <0.0001 | <0.0059 |
| CD8+ CD28- CD27- CD57+ | 80 (86) | 71 (78) | −9 | ns | ns | |
| CD8+ KLRG1+ | 131 (112) | 79 (105) | −52 | 0.0126 | ns | |
| CD4+ CD28− | 18 (33) | 32 (74) | 14 | ns | ns |
Mean and standard deviation (SD) of absolute cell counts pre-treatment (Pre) and on-treatment (On) for major T-cell subsets are shown in cells/µL (n = 20–32). The differences between on- and pre-treatment counts are shown. The results of paired t-tests comparing the two timepoints are shown both unadjusted and after Bonferroni correction for multiple comparisons. ns = not significant.