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. 2020 Jan 15;10:403. doi: 10.1038/s41598-019-57317-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Overview of methodological setup. Ultrasound B-mode and SWE imaging is performed, providing both spatiotemporal group velocity (time-domain) and frequency-dependent phase velocity (after Fourier transform, $ℱ$ ). Velocities are validated and correlated with MRI-derived plaque components, as well as AHA type classification. For the ultrasound and SWE panels, the plaque is delineated in blue. In the MR-vessel wall imaging (VWI) panel, one of the 2D black-blood VWI series is displayed with the analysis from MRI PlaqueView superimposed including the lipid-rich necrotic core (LRNC, yellow), intraplaque hemorrhage (IPH, red), calcifications (CA, white), loose matrix (purple), and vessel outline (blue). In the 3D volume rendering (VR) MR angiography (MRA) + VWI panel, the detected plaque components are superimposed on the MRA and displayed as a volume rendered image using the same color scheme.