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. 2020 Jan 15;10:353. doi: 10.1038/s41598-019-57257-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Metabolites Correlated with Insulin Sensitivity. (a–l) Pearson’s correlation analysis was performed between the intensity of metabolites at basal level and OGIS with corrplot package implemented in R 3.2.5. A correlation coefficient with a p-value of <0.05 was considered as significant. Estimated marginal means (EMM) adjusted for age was used for representation. Error bar represents standard error (SE). P-values were reported based on ANCOVA after adjusting age. Correlation coefficients and p-values from ANCOVA analysis are labeled in the figure and correlation coefficient values are provided in Supplementary Table S5.