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. 2020 Jan 15;10:311. doi: 10.1038/s41598-019-56983-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Collective cell migration reaches a maximum at 23 Pa CSS in LN229 and U251 cells. Differential wound closure: the difference of each compression level (agar control, 13 Pa, 23 Pa, 47 Pa, and 115 Pa) from its corresponding experimental control. Levels connected by a star (*) are statistically significant at α = 0.05. Conditions marked with two stars (**) are statistically significant compared to their control for each cell type at α = 0.01 after Bonferroni correction.