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. 2020 Jan 15;10:311. doi: 10.1038/s41598-019-56983-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IPA analysis of canonical pathways and cellular functions at low CSS (23 Pa). (A) Top canonical pathways ranked by -log(p value). Overlap, indicated on the right axis, is calculated as the number of differentially regulated genes in the pathway over the number of total genes in that pathway. (B) Top molecular and cellular functions ranked by -log(p value). Overlap, shown on the right axis, is the number of differentially regulated genes related to that function over total number of differentially expressed genes. Z scores higher than 2 indicate pathway activation/ cell function increase, z scores lower than -2 indicate pathway suppression/ cell function decrease.