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. 2020 Jan 15;10:311. doi: 10.1038/s41598-019-56983-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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miRNA-mRNA interactions show miRNA and pathway group dysregulation. (A) The total number of miRNA with target mRNA that interact with a given pathway. (B) Percent overlap for each miRNA-pathway pair. Percent overlap: the % of mRNA targets that were differentially regulated. (C) Cumulative absolute fold change (FC) for each miRNA-pathway pair. Cumulative absolute FC: the cumulative unsigned fold change of the differentially regulated targets. A total of 167 pathways were classified into functional groups: I: Cancer, II: Motility, III: DNA Repair, IV: Cell Cycle, V: Apoptosis, VI: Miscellaneous, VII: Canonical. The 27 miRNA were split by their relevance to GBM. miRNA denoted with a hashtag (#) denotes a substitution for a miRNA included in a host gene.